Replevé is an innovative hybrid injectable biostimulator designed to
deliver immediate hydration and glow (via HA), while simultaneously activating long-term neocollagenesis (via PLLA + Tripeptides). The unique peptide combination ensures strong, abundant collagen synthesis (Tripeptide-5) and organized,
high-quality fibers (Tripeptide-10), reducing the risk of fibrosis or
irregular deposition.

Mechanism of Action

1. PLLA Microspheres (365 mg):

• Induce controlled fibroblast activation
• Promote type I & III collagen synthesis over 18–24 months.
• Provide natural, gradual volumization.

2.Hyaluronic Acid:

• Immediate hydration and dermal plumping.
• ECM support and improved skin texture.

3.Tripeptide-10 Citrulline:

• Biomimetic of decorin, regulating collagen fibrillogenesis.
• Ensures uniform, elastic collagen fiber deposition.

4.Tripeptide-5:

• Stimulates TGF-β pathway to increase collagen synthesis.
• Protects against collagen breakdown by inhibiting MMPs

Indications

• Facial volume restoration (midface, temples, jawline).
• Skin laxity and atrophy of face, neck, décolletage, arms,
  abdomen.
• Buttock and body biostimulation/contouring.
• Improvement of skin elasticity, density, and firmness.
• Comprehensive bio-rejuvenation for prevention of aging.

Injection Protocol

• Reconstitution: Add Vial B (10 mL solution of HA + Tripeptides) into Vial A (PLLA powder). Shake until homogeneous suspension. Allow 15–20 min for full hydration of microspheres.

Technique:

• Subdermal or supraperiosteal injection with 25–27G cannula or 26–27G needle.
• Small aliquots, fan/threading technique.
• Gentle massage post-injection to distribute evenly.

Treatment Sessions:

• Face: 2–3 sessions, 6–8 weeks apart.
• Body: 2–4 sessions, 6–8 weeks apart.
• Duration of Results: 18–24 months, maintenance at ~18 months.

Clinical Benefits

• Immediate hydration and glow (HA)
• Long-lasting collagen stimulation (PLLA + Tripeptide-5).
• High-quality collagen organization (Tripeptide-10).
• Elastic, firm, natural results with minimized fibrosis/nodule risk.
• Dual-phase action: short-term skin improvement + long-term
  structural regeneration.

1 Box contains:

• 1 Vial (PLLA 365 mg lyophilized powder)
• 1 Vial (10 mL HA + Tripeptide-10 + Tripeptide-5 solution)